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Depending on the patient's pain threshold, and while some patients may forgo anesthesia altogether, most patients will require some form of local anesthesia. Pre-treatment might include the application of an anesthetic cream under occlusion for 45 to 90 minutes prior to the laser treatment session. If complete anesthesia is desired, it can be administered locally by injections of 1% to 2% lidocaine with epinephrine.
Anecdotal reports have noted that patients receiving anesthesia by local injection will require additional treatments as the injection causes mechanical edema, spreading out the tattoo ink, which in turn makes it more difficult for the laser light to act on specific ink particles. It has been reported that infiltration of local anesthesia will add an additional treatment or two.
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
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